Nutritional supplements may be important on cognition but the evidence is heterogeneous. This meta-analysis aimed (1) to determine whether nutritional supplements provided to pregnant women or young children could improve cognitive development of children in developing countries, and (2) to explo...

PURPOSE: To evaluate the effect of folate and folate plus zinc supplementation on endocrine parameters and sperm characteristics in sub fertile men. MATERIALS AND METHODS: We conducted a systematic review and meta-analysis. Electronic databases of Medline, Scopus , Google scholar and Persian data...

OBJECTIVE: To report an update on the role of vitamin D (VD) in ovarian physiology with a focus on genes involved in steroidogenesis, follicular development, and ovarian reserve, as well as ovulatory dysfunction associated with polycystic ovary syndrome (PCOS), and ovarian response to assisted re...

Inadequate sleep (i.e., duration and/or quality) is becoming increasingly recognized as a global public health issue. Interaction via the gut-brain axis suggests that modification of the gut microbial environment via supplementation with live microorganisms (probiotics) or nonviable microorganism...

Obesity and overweight are independent risk factors of erectile dysfunction (ED). It is controversial whether weight loss can improve erectile function. We thereby performed this meta-analysis to clarify the therapeutic effect of weight loss on erectile function in overweight or obese men. Litera...

BACKGROUND: Some diet factors are risk factors for dental erosion. METHODS: We performed computer searches of PubMed, Cochrane Library, EBSCO, CALIS, et al., to search for studies investigating risk factors for dental erosion. For risk factors investigated in a comparative way, we computed pooled...

背景:辅助维生素D治疗肺结核(TB)的随机对照试验得出了相互矛盾的结果。个体参与者数据荟萃分析可以确定解释这种差异的因素。方法:我们荟萃分析了接受抗菌药物治疗的肺结核患者维生素D随机对照试验的个体参与者数据。主要观察指标为痰培养转化时间。次要结果为痰涂片转换时间、平均8周体重和不良事件发生率。根据基线维生素D状况、年龄、性别、药物敏感性、HIV状况、疾病程度和维生素D受体基因型进行预先指定的亚组分析。结果:在8项研究中获得了1850名参与者的个人数据。维生素D总体上不影响痰培养转化的时间(调整后的风险比1.06,95% CI 0.91-1.23)，但它确实加速了耐多药肺结核患者的痰培养转...

BACKGROUND: A previous aggregate data meta-analysis of randomised controlled trials showed that vitamin D supplementation reduces the rate of asthma exacerbations requiring treatment with systemic corticosteroids. Whether this effect is restricted to patients with low baseline vitamin D status is...

BACKGROUND: Randomised controlled trials (RCTs) of vitamin D to prevent COPD exacerbations have yielded conflicting results.Individual participant data meta-analysis could identify factors that explain this variation. METHODS: PubMed, Embase, the Cochrane Central Register of Controlled Trials and...

The association between coffee consumption and pancreatic cancer risk has been extensively studied; however, there is no consistent conclusion. Therefore, this meta-analysis study sought to evaluate dose-response relationship between them. A search was conducted using the PubMed and Web of Scienc...