Objective: To review the effectiveness of exercise therapy in patients with osteoarthritis (OA) of the hip or knee. Methods: A computerized literature search of Medline, Embase, and Cinahl was carried out. Randomized clinical trials on exercise therapy for OA of the hip or knee were selected if ...

Meta-analysis techniques have been used to accumulate data from 94 studies describing the natural killer (NK) cell response of some 900 volunteers to acute and chronic exercise. NK cell numbers have been indicated in terms of CD3-CD16+CD56+, CD16+ or CD56+ phenotypes, and cytolytic activity has b...

OGectiue: To reconcile conflicting reports concerning the incidence of otorrhea in children with tympanostomy tubes who swim without ear protection. Study Selection: Articles were identified by MEDLINE search, Current Contents, and references from review articles, textbook chapters, and ret...

我们试图评估饮用咖啡对人类血压的影响。我们的数据来源包括对1997年12月之前发表的文献的MEDLINE搜索、参考文献综述和专家咨询。我们选择了干预组和对照组之间唯一不同的对照试验，报告各组或每个时期的平均血压变化，治疗持续时间>24小时。在最初确定的36项研究中，11项（522名参与者）符合这些纳入标准。关于样本量、研究设计、参与者特征（性别、种族、年龄、基线血压和抗高血压药物）和治疗结果的信息由3名评审员使用标准化方案提取。使用随机效应模型估计咖啡消费对血压的治疗效果。在11项试验中，中位持续时间为56天（范围为14至79天），咖啡的中位剂量为5杯/天。与对照组相比，咖啡治疗的收缩压...

Practice guidelines such as those of the United States Public Health Service Agency for Health Care Policy and Research have been instrumental in addressing the significant problem of how best to manage major depression in primary medical care settings. Since this set of guidelines was published ...

Nine double-blind, placebo-controlled medication trials (870 subjects) and 26 randomized psychosocial studies (460 subjects) were included in a meta-analysis of bulimia nervosa (BN). Four treatment outcomes were analyzed: binge and purge frequency, depression (self-reported and interviewer-rate...

Objective: To evaluate and compare the efficacy of pharmacological and nonpharmacological treatments of fibromyalgia syndrome (FMS). Methods: This meta-analysis of 49 fibromyalgia treatment outcome studies assessed the efficacy of pharmacological and nonpharmacological treatment across four ...

BACKGROUND: There is compelling evidence that estrogens influence breast cancer risk. Since the mid-1980s, dietary fat intervention studies have been conducted to investigate the effect of fat intake on endogenous estrogen levels. To further our understanding of the possible relationship between ...

OBJECTIVE: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. DESIGN: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. SUBJECTS: Nine published trials...