Introduction: Chest tube removal for patients with painful, annoying and worrisome process. So as to relief the pain experienced by the patients which pharmacologic and nonpharmacologic pain relief methods can be applied. Objectives: The aim of this systematic reseach to evaluate the effectiveness of pharmacologic and nonpharmacologic pain management methods that used to chest tube removal. Material/Patients and Methods: in this study we used three databases (PubMed, CINAHL, WEB OF SCIENCE) to obtain the initial list of potential articles for systematic review. Researches included published articles covering the period from 2003 to 2013. Research terms included,“chest tube”,“pain”, and“removal”. Inclusion criteria for this research articles can be written in English and should be a research article. Exclusion criteria; not to be in English, not to be a research article and studies which was performed for pediatrics. Potantially relevant 8 studies were evaluated for this study. Results: Seven of the studies which analyzed randomized controlled trials and three of them double-blind, placebo-controlled study. One of these studies design was two-group quasi-experimental pretest/posttest the greater part of the studies suggest that the effect of pharmacological methods. However some of these studies shown that nonpharmacologic methods which is including the cold application methods or relaxation exercises indicates a statistically significant decrease with chest tube removal pain. Conclusion: The studies suggest that pharmacologic and nonpharmacologic methods is effective in pain management for these patients. However, in the literature there are limited studies that used the combination of these both methods to provide effective pain management for these patients for this reason randomized controlled trials on this subject are recommended.