Knee osteoarthritis is a leading cause of disability and medical costs. Osteoarthritis leads to pain, stiffness, swelling and loss of function, resulting in poor quality of life. Whole-body vibration is a non-invasive treatment that has been proposed to improve muscle strength and physical performance. This analysis of 14 randomized controlled trials showed that, compared with exercise alone, wholebody vibration with exercise had positive effects on pain, physical function, and knee extensor muscle strength in patients with knee osteoarthritis. Based on these findings, we recommend whole-body vibration used together with strengthening exercises for knee osteoarthritis.