Background & Objective: Irisin is considered as a candidate to treat obesity and metabolic diseases. Therefore, the aim of this study was a systematic review and meta-analysis to define the effective modes of exercise on irisin concentration in adults. Materials & Methods: Google Scholar, PubMed, Medline, Scopus, Science Direct, and references lists of articles were searched until April 25, 2020. To study the impact of exercise duration (short-term and long-term) on the pre-test and post-test concentration of irisin, 21 studies with 384 subjects were evaluated. Results: In the present study, a significant increase was found in irisin level in long-term resistance training (LTRT) intervention groups (MD:-0.61 ng/ml, 95% CI [-1.12, 0.09], P=0.02). However, no significant changes were reported in the groups of long- term aerobic training, short-term aerobic training, and short + long term aerobic training. Conclusion: The analysis showed that only LTRT among the types of exercise can elevate irisin concentration. Therefore, LTRT seems to have more beneficial influences, compared to other modes of exercise in inclusive irisin responses.