Pharmacological therapies for menopausal symptoms have limited effectiveness and are associated with serious adverse events. Therefore, many menopausalwomen use complementary therapies to cope with their symptoms, and yoga and mindfulness-based stress reduction (MBSR) are among the most commonly used complementary therapies. Aim: The aim of this systematic review was to assess and meta-analyse the efficacy of yoga and of MBSR for menopausal symptoms. Methods: Medline, Scopus, the Cochrane Library, and PsycINFO were searched through April 2012. Randomised controlled trials (RCTs) comparing yoga or MBSR to control conditions were analysed when they assessed major menopausal symptoms, namely (1) psychological symptoms, (2) somatic symptoms, (3) vasomotor symptoms and/or (4) urogenital symptoms. Safety was defined as a secondary outcome measure. If at least two studies assessing a specific outcome were available, standardised mean differences (SMDs) and 95% confidence intervals (CIs) were calculated. Risk of biaswas assessed by two reviewers independently using the risk of bias tool recommended by the Cochrane Back Review Group. Results: Five RCTs on yoga with a total of 582 participants were included. Two RCTs had low risk of bias. Two RCTs compared yoga to no treatment, one RCT compared yoga to exercise and two 3-arm RCTs compared yoga to no treatment and exercise. Therewas moderate evidence for short-term effects on psychological symptoms (SMD = -0.37, 95% CI -0.67 to -0.07, P = 0.02). No evidence was found for effects on total menopausal symptoms (SMD = -0.53, 95% CI -1.19 to 0.14, P = 0.12), somatic symptoms (SMD = -0.26, 95% CI -0.76 to 0.25, P = 0.32), vasomotor symptoms (SMD = -0.04, 95% CI -0.68 to 0.60, P = 0.90) or urogenital symptoms (SMD = -0.37, 95% CI -1.14 to 0.40, P = 0.34). Yoga was not associated with serious adverse events. One low-risk RCT on MBSR with a total of 110 patients was included. This RCT reported short-term and long-term effects of MBSR compared to no treatment on psychological symptoms. No serious adverse events due to MBSR were reported. Conclusions: This systematic review found moderate evidence for efficacy of yoga and limited evidence for efficacy of MBSR for psychological symptoms in menopausal women. Given the lack of safe, evidence-based treatment options for menopausal symptoms, yoga can be preliminarily recommended as an additional intervention to women who suffer from psychological complaints associated with menopause.