Background When applying aquatic exercise program to patients with neurological disorder, quality of life (QOL) can be changed by physical function or psychological improvement. Methods Cochrane Database, CINAHL, Embase, Google Scholar, PEDro, PubMed, ScienceDirect, and SCOPUS were used to systematically search for relevant studies published between January 1999 and June 2019. The study quality was determined using the Physiotherapy Evidence Database (PEDro) scale. Results Eight of the 326 retrieved articles met the inclusion criteria. The results of the studies led to a general consensus: physical education program increased balance and gait and decreased pain. QOL improved as physical health, mental health, and vitality recuperated. Conclusions The findings indicate that aquatic exercise program could be helpful when treating neurological disorders and should be considered as a means of reducing pain while increasing physical function and QOL in standard clinical research programs.