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The association between leisure time physical activity and pancreatic cancer risk in adults: A systematic review and meta-analysis

作者:M. S. Farris

关键词:behavior change cancer risk human leisure leisure time physical activity Medline meta analysis motor activity pancreas cancer physical activity priority journal review risk reduction systematic review Pancreatic Neoplasms Leisure Activities

发表时间:2015

发表期刊:Reviews

证据类型:系统评价/Meta分析

We conducted a meta-analysis of the association between leisure time physical activity (LTPA) and risk of pancreatic cancer to update previous analyses in light of newly published studies, to examine subgroups of interest and potential sources of heterogeneity. We searched the PubMed and MEDLINE databases for studies until February 2015. Study information was collected using a standardized form to abstract relevant data on study design, number of cases, participant and study characteristics, assessment of LTPA, risk estimates, and adjustments for confounding by two independent abstractors. We used random effects models to pool estimates from included studies of lowest versus highest comparison of LTPA. The search identified 26 studies eligible for inclusion into the meta-analysis. The combined summary risk estimate was [relative risk (RR), 0.89; 95% confidence interval (CI), 0.82-0.96]. There was evidence of heterogeneity across studies (I<sup>2</sup>= 22.1%, P<inf>heterogeneity</inf> = 0.130). Some of the heterogeneity could be explained by study design, with stronger protective effects observed among case-control studies (RR, 0.69; 95% CI, 0.59-0.81) compared with cohort studies (RR, 0.96; 95% CI, 0.91-1.02). Across study designs, age of population was a source of heterogeneity, with stronger effects observed among younger (<50 years) populations. The present meta-analysis supports a protective association between LTPA and pancreatic cancer with an 11% risk reduction observed. LTPA appears to have the strongest effect among young populations. Additional investigations are needed to provide insights regarding the impact of LTPA in healthy adult populations, to reduce the risk of pancreatic cancer and encourage increases in LTPA.