Objective: The convoluted element of PM2.5 may cause various biological reactions. Nowadays, few studies have indicated the long-term health efects of PM2.5 on HCC. Therefore, this meta-analysis frst aims to obtain more precise estimates of the efects of PM2.5 exposure on HCC to assess the strength of the evidence. Methods: A combination of computer and manual retrieval was used to search in Medline through PubMed, EMBASE and Web of Science. Review Manager 5.3 software was used to examine the heterogeneity among the studies. Results: Finally, 8 qualifed articles meet the inclusion criteria. The results were I2=0%, P>0.1 indicating that there was no heterogeneity. The results showed that the concentration of PM2.5 increased by 10 μg/m3 was signifcantly correlated with liver cancer, and HR was 1.22 (95% CI 1.14–1.30, P<0.05), indicating that maternal exposure to PM2.5 was positively correlated with liver cancer. Conclusions: Our meta-analysis showed that the patients with HCC signifcance related to PM2.5 exposure. However, more studies investigating the combined efects of diferent air pollutants on HCC incidence are warranted to provide more comprehensive evidence for assessing the diferent levels impacts of PM2.5 exposure on HCC incidence.