作者:Fang, Y. Y
关键词:Prostatecancer Exercise Socialfunction Cognitivefunction
发表时间:2020
发表期刊:Supportive Care in Cancer
证据类型:系统评价/Meta分析
Purpose Exercise is beneficial for prostate cancer patients’ physical functioning; however, effects on social and cognitive functioning are inconsistent. This meta-analysis of exercise interventions for prostate cancer patients had two aims: the primary aim was to evaluate the effects of exercise interventions on social functioning; the secondary aim was to consider additional outcomes of cognitive functioning as well as adverse events. Methods Electronicdatabases(Embase,MEDLINE,PubMed,PsycINFO,andtheChinesedatabaseAirtiLibrary)weresearched for relevant papers (1987–2019), which included hand searching. After careful inspection, 10 relevant randomized controlled trials were analyzed using Comprehensive Meta-Analysis software; pooled means determined social and cognitive functioning. Results Meta-analysis of summary scores (fixed-effects model) showed an overall beneficial effect of exercise on social func- tioning (Hedges’ g=0.35, 95% CI [0.193, 0.515], p<0.001) and cognitive functioning (Hedges’ g=0.35, 95% CI [0.123, 0.575], p<0.01) in men with prostate cancer when compared to controls. Intervention durations of 12–16 and 24–48 weeks that provided supervised aerobic exercise combined with resistance exercise sessions had a small to medium effect on social functioning compared to controls. One exercise group experienced one serious, but non-fatal, adverse event due to a higher exercise intensity (50–75% VO 2 max). Discussion and recommendations To the best of our knowledge, this is the first meta-analysis to examine the effects of exercise interventionsoncognitivefunctioningamongprostatecancerpatients.