Aims: The aim of this review is to synthesize and evaluate effectiveness of exergaming on balance, lower limb functional mobility and functional independence in individuals with chronic stroke. Design: The present review is a systematic review and meta- analysis. The review is written in accordance with the guidelines from the Preferred Reporting Items for Systematic Review and Meta- Analysis (PRISMA) Data Source: Searches were conducted across seven databases (PubMed, EMBASE, Web of Science, CINAHL, CENTRAL, Scopus and PEDro) and in grey literature from inception until January 2021. Review Methods: Only randomized controlled trials (RCTs) written in English were included. All eligible studies were assessed for risk of bias by two reviewers indepen- dently. Meta- analyses were performed using RevMan 5.4.1 software. Narrative syn- theses were adopted whenever meta- analysis was inappropriate. The overall quality of evidence from included studies was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. Results: 4511 records were retrieved, with 32 RCTs eligible for inclusion and 27 RCTs included in meta- analysis. Meta- analyses reported statistically significant small ef- fect sizes favouring exergaming on balance (pooled standardized mean difference [SMD] = 0.25, 95% confidence interval [CI, 0.08– 0.41], p = .004), lower limb func- tional mobility (pooled SMD = 0.29, 95% CI [0.08– 0.50], p = .007) and functional independence (pooled SMD = 0.41, 95% CI [0.09– 0.73], p = .01). Most of the included studies failed to provide adequate description of the measures taken to prevent bias. Conclusion: Exergaming has favourable effects on improving balance, lower limb functional mobility and functional independence among individuals with chronic stroke, making it a suitable adjunct to conventional physiotherapy. Impact: People with chronic stroke have difficulty achieving the required rehab inten- sity. Exergaming can help individuals with chronic stroke to undertake further rehabil- itation exercises at home. It can be a suitable adjunct to conventional physiotherapy