Objective: The role of kinesiotherapy in heterotopic ossification (HO) remains unclear. The goal of this study is to revisit the literature on the preventive role of kinesiotherapy against HO formation and maturation. Design: A systematic review was performed in MEDLINE, OVID, SCOPUS and Cochrane databases. Results: A high-quality clinical trial is missing from the literature. Out of 9617 studies primarily identified, 9 studies offered the proper data and were included. They infer that satisfactory results on neurogenic HO prevention were achieved with passive exercises, including continuous passive motion (CPM), that were initiated early and at a painless range of motion (ROM). On the contrary, for elbow post-traumatic HO and major joints burn-associated HO, active ROM is indicated as early as possible. Conclusion: Due to the very low quality of the studies included in this review, firm conclusions cannot be drawn about the effectiveness of kinesiotherapy. Nevertheless, it is recommended that controlled passive ROM (PROM) exercises (especially CPM) be applied early and pain-free especially in the neurogenic HO patients while active ROM in painless limits is beneficial in the HO prevention of traumatic elbows or burn joints.