作者:Yu XB
关键词:
发表时间:2014
发表期刊:PLoS One
证据类型:系统评价/Meta分析
Background and Purpose: Currently there are more and more studies on the association between short-term effects of exposure to particulate matter (PM) and the morbidity of stroke attack, but few have focused on stroke subtypes. The objective of this study is to assess the relationship between PM and stroke subtypes attack, which is uncertain now. Methods: Meta-analyses, meta-regression and subgroup analyses were conducted to investigate the association between short-term effects of exposure to PM and the morbidity of different stroke subtypes from a number of epidemiologic studies (from 1997 to 2012). Results: Nineteen articles were identified. Odds ratio (OR) of stroke attack associated with particular matter (‘‘thoracic particles’’ [PM10],10 mm in aerodynamic diameter, ‘‘fine particles’’ [PM2.5], 2.5 mm in aerodynamic diameter) increment of 10 mg/m3 was as effect size. PM10 exposure was related to an increase in risk of stroke attack (OR per 10 mg/m3 = 1.004, 95%CI: 1.001,1.008) and PM2.5 exposure was not significantly associated with stroke attack (OR per 10 mg/m3 = 0.999, 95%CI: 0.994,1.003). But when focused on stroke subtypes, PM2.5(OR per 10 mg/m3 = 1.025; 95%CI, 1.001,1.049) and PM10 (OR per 10 mg/m3 = 1.013; 95%CI, 1.001,1.025) exposure were statistically significantly associated with an increased risk of ischemic stroke attack, while PM2.5(all the studies showed no significant association) and PM10(OR per 10 mg/m3 = 1.007; 95%CI, 0.992,1.022) exposure were not associated with an increased risk of hemorrhagic stroke attack. Meta-regression found study design and area were two effective covariates. Conclusion: PM2.5 and PM10 had different effects on different stroke subtypes. In the future, it’s worthwhile to study the effects of PM to ischemic stroke and hemorrhagic stroke, respectively.