Music may have a role in reducing anxiety related to cardiac catheterization procedures. This comprehensive systematic review and meta-analysis of randomized clinical trials sought to evaluate the extent to which music reduce anxiety in patients undergoing cardiac catheterization. MEDLINE, EMBASE, CENTRAL, AMED, and PsychINFO were examined up until May 1 2015. Study quality and risk of bias were assessed using the JADAD scale. Spielberger state anxiety inventory (STAI-S) served as our primary outcome. A total of 15 studies were found to be eligible for inclusion (14 published trials and one conference abstract) in this review. Two-thirds of these studies showed statistically significant improvement in anxiety with music-based interventions. Metaanalysis included six studies (n=695) and showed statistically significant reduction in mean STAI-S scores with music ( -3.95 points; 95% confidence -5.53 and -2.37; p value less than 0.005). In conclusion, music can have significant anxiolytic effects for patients undergoing cardiac catheterization.