Mindfulness-based therapies are rising in popularity. However, evidence for their efectiveness in reducing psychological distress and enhancing wellbeing for families living with autism spectrum disorder (ASD) is limited. A systematic search identifed 10 independent studies, involving a pooled sample of 233 children and adults with ASD and 241 caregivers. Hedges’ g efect sizes with associated 95% confdence intervals, in addition to heterogeneity, were calculated using a random-efects model. Caregivers, children and adults who received mindfulness all reported signifcant gains in subjective wellbeing immediately post-intervention. Available data indicated intervention efects were maintained at 3-month follow-up. Mindfulness presents a promising intervention strategy in ASD populations, however more controlled research is required to determine its precise efcacy for afected families and subgroups.