Objective: Psychotherapy is a common non-pharmacological approach to help cancer patients in their psychological distress. The benefit of psychotherapies was documented, but the types of psychotherapies proposed are varied. Given that the previous literature review was a decade ago and no quantitative analysis was done on this topic, we again critically and systematically reviewed all published trials on psychotherapy in cancer patients. Method: We identified 17 clinical trials on six types of psychotherapy for cancer patients by searching PubMed and EMBASE. Result: There were four trials involved adjunct psychological therapy which were included in quantitative analysis. Each trial demonstrated that psychotherapy improved the quality of life and coping in cancer patients. There was also a reduction in distress, anxiety, and depression after a psychological intervention. However, the number and quality of clinical trials for each type of psychotherapy were poor. The meta-analysis of the four trials involved adjunct psychological therapy showed no significant change in depression, with only significant short-term improvement in anxiety but not up to a year—the standardized mean differences were  0.37 (95% confidence interval (CI) ¼ 0.57,  0.16) at 2 months,  0.21 (95% CI ¼ 0.42,  0.01) at 4 months, and 0.03 (95 % CI ¼ 0.19, 0.24) at 12 months.Conclusion: The evidence on the efficacy of psychotherapy in cancer patients is unsatisfactory. There is a need for more rigorous and well-designed clinical trials on this topic. Keywords psychotherapy, cancer, oncology, anxiety, depression