The purpose of this systematic review was to explore psychological interventions applied to patients with systemic lupus erythematosus (SLE) and analyze their usefulness in promoting a favorable adaptation in the psychological, social and physical area. A comprehensive search bases Scopus, Medline, PsycINFO and Cochrane Library data was performed and empirical research published between 2005 and 2016 were selected studies reflected different therapeutic options: cognitive behavioral therapy, emotional writing, and mindfulness training a combination of group psychoeducation and psychotherapy. The results show that these interventions can positively impact the quality of life, anxiety, depression, stress, mental health, body image, disease management, interpersonal relationships, fatigue, and pain. However, studies have significant methodological limitations that prevent definitive conclusions. Therefore, it is considered essential to perform randomized controlled trials of higher methodological quality to quantify the effectiveness of psychological interventions in SLE and establish the superiority of one treatment over another.