Background: Burn injuries may have both physiological and psychological consequences. Numerous studies have reported the use of music therapy during burn injury treatment, but the optimal timing for music therapy remains unclear. Therefore, we performed a systematic review and meta-analysis of randomized controlled trials on patients with burn injuries to analyze the effects of music intervention on them at different timings: background (T0) and time before (T1), during (T2), and after (T3) change dressing (CD). Method: The PubMed and EMBASE databases were searched for articles published before Novenber 2020 based on predetermined criteria. Our search focused on two keywords: music and burn. Reviewers extracted data from all eligible studies independently. The I2 statistic was used to determine statistical heterogeneity. The endpoints included standardized mean differences (SMDs) and 95% confidence intervals (CIs). Relevant Forest plots were also created. Result: This study finally included seven trials recruiting a total of 524 patients. The results indicated that compared with non-music intervention, music intervention significantly reduced anxiety at T0 (SMD =
1.32, 95% CI [
2.61,
0.02], T1 (SMD =
2.15, 95% CI [
4.30,
0.00]) and T2 (SMD =
0.39, 95% CI [
0.74,
0.04]). Moreover, they also significantly reduced the pain levels at T0 (SMD =
1.59, 95% CI [
2.00,
1.17]) and T2 (SMD =
0.47, 95% CI [
0.82,
0.12]), improved the mental condition, and reduced the amount of opioid analgesics used at T0.