Background: Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek diferent self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was to perform a systematic review and meta-analysis about the use and efect of CAM modalities to treat adverse efects of conventional cancer treatment among children and young adults. Methods: Six scientifc research databases were used to identify randomized controlled trials (RCTs) from 1990 to September 2020. Included studies investigated the use of CAM to treat cancer treatment related adverse efects in children and young adults compared to controls. Results: Twenty RCTs comprising 1,069 participants were included in this review. The included studies investigated acupuncture, mind–body therapies, supplements, and vitamins for chemotherapy-induced nausea and vomiting (CINV), oral mucositis, and anxiety among children and young adults who underwent conventional cancer treatment. Seven studies (315 participants) were included in the meta-analysis. The overall efect of CAM (including acupuncture and hypnosis only) on chemotherapy-induced nausea and/or vomiting and controls was statistically signifcant with a standard mean diference of -0.54, 95% CI [-0.77, -0.31] I 2=0% (p<0.00001). There was a signifcant diference between acupuncture and controls (n=5) for intensity and/or episodes of CINV with an SMD -0.59, 95% CI [-0.85, -0.33] (p<0.00001). No signifcant diference was found between hypnosis and controls (n=2) for severity or episodes of CINV with an SMD -0.41, 95% CI [-1.09, 0.27] I 2=41% (p=0.19). Conclusion: Current evidence from this meta-analysis of randomized controlled trials shows that CAM, including acupuncture and hypnosis only, is efective in reducing chemotherapy-induced nausea and vomiting in children andyoung adults. More rigorous trials and long-term efects should be investigated if acupuncture and hypnosis are to be recommended for clinical use. Keywords: Complementary and alternative medicine (CAM), Pediatric oncology, Adverse efects, Chemotherapyinduced nausea and vomiting (CINV)