Background: Acceptance and Commitment Therapy (ACT) is the most prominent among the ‘third wave’ psy­ chotherapies. This is the first systematic review that evaluates the current body of evidence for the efficacy of ACT as a therapeutic modality in OCD. Method: A comprehensive literature search was conducted on the PubMed and Medline databases. The publi­ cations thus obtained were screened by title, abstract, and main text. Articles meeting the defined inclusion and exclusion criteria were assessed, and the results presented under the relevant sub-headings, to depict the various study designs employed in the included studies. Results: Out of 690 articles that were evaluated, 16 articles were finally included in the review. ACT was found to produce a significant decrease in OCD symptoms, with the gains largely being maintained at follow-up. Although ACT was more effective than control conditions like wait-list and placebo, it did not outperform the established frontline psychological treatments for OCD, i.e., traditional CBT and ERP. However, when combined with pharmacological management, ACT was comparable to a combination of CBT and pharmacotherapy in treating OCD. Conclusion: There is potential evidence to support the utility of ACT as a therapeutic intervention in OCD when used in combination with pharmacotherapy.