Objective(s) To identify effects of Tai Chi practice on inflammatory biomarkers. Data Sources With PubMed, Scopus, Medline, PEDro, and CINAHL search engines, Tai Ji, Tai Chi, Tai Chi Quan, biomarkers, cytokines, inflammatory, and inflammation were used to search in peer-reviewed English journals from last 10 years until July 2020. Inclusion criteria were randomized control trials (RCT) with Tai Chi as one of interventions in subjects who were 18 years and older. Study Selection One-hundred nineteen articles met the criteria through scanning the titles, abstracts, and keywords initially and then by discussion if needed by 3 reviewers. Data Extraction With PRISMA method for evaluation, 16 RCT studies were qualified for further analysis. Data extracted included participant and exercise characteristics, the outcomes measures, and study results. Data Synthesis These studies include 7 in adults with cancers. 3 in community-dwelling older adults, and 1 in older adults with HIV, depression, metabolic syndrome, periodontal disease, amnesia, or chronic pain. Decreased proinflammatory contributors were found including interleukins (IL-1, 2, 6, 8, 12,), Tumor necrosis factor (TNF-α), interferon (IFN-γ), Necrotic factor (NF-kβ), C-reactive protein, soluble cell adhesion molecule, and peripheral monocytes like CD14+ and CD16+ monocytes; while increased anti-inflammatory cytokines were only found in IL-10 and 13. The changes of these biomarkers seemed not associated with the subjects’ medical conditions. Improved anti-inflammatory responses are seen in studies with exercise parameters of 60 minutes/each, 3 times or more each week for a minimum of 12 weeks. Conclusions Tai Chi is an excellent exercise program to improve body anti-inflammatory capacity, primarily through the inhibition of pro-inflammatory biomarkers. Regardless of medical conditions, a person can benefit from practicing TC with proper exercise parameters.