Objective: Preliminary evidence suggests that Tai Chi (TC) improves selected cardiovascular (CV) risk factors and psychological symptoms in adults with CV disease (CVD). Previous reviews have focused on specific conditions, thus limiting the number of included studies. At present, we have not had a comprehensive evaluation of the effects of TC on CV risk factors and psychological health; missing have been estimates of the effects across all CV conditions and how intervention dose and other characteristics may modify intervention effects. This systematic review and metaanalysis evaluated the efficacy of TC on psychological and CV outcomes in adults with CVD and potential moderators of intervention efficacy (e.g., TC dose, sample characteristics, home practice). Methods: We conducted systematic searches in 10 bibliographic databases. Records were eligible if (a) the study evaluated TC compared to a control condition, (b) sampled adults with CVD, and (c) reported physical and/or psychological outcomes. Sample/intervention characteristics were extracted by two coders. Results: A qualitative summary is reported; final quantitative analyses will be available at the conference. Forty studies reported on 42 TC interventions (40/42 TC only; 2 multi-component). Sample sizes ranged from 16 to 1,084 (M age=65 years; 43% women). CV conditions included hypertension (12), heart failure (11), stroke (5), CHD (10) or any CVD (2). The median number of sessions was 24 (range: 10-468). Sixteen studies included home practice recommendations. Compared to controls, TC reduced depressive symptoms in 8/12 studies. Systolic and diastolic blood pressure was improved in 14/20 and 10/19 studies, respectively. Anxiety was reduced in 2/4 studies. Lipids showed mixed results (total cholesterol: 2/7; low-density lipoprotein: 3/7; triglycerides: 3/7). Conclusion: TC reduces depressive symptoms and blood pressure in adults with CVD. Quantitative meta-analytic assessments will summarize the effects of TC on CV outcomes and the role of important moderators of TC effect.