Purpose The aim of this review is to systematically review randomized controlled trials on lifestyle interventions on PCa patients undergoing androgen deprivation therapy. Methods A literature search was conducted using the electronic databases Medline and PubMed. To be eligible, studies had to be randomized controlled trials (RCTs) that focused on side efects of ADT and lifestyle interventions to reduce side efects for men undergoing ADT with PCa. Lifestyle interventions were defned as interventions that included any dietary or behavioral components. Results Twenty-nine trials were included. Most of them focused on exercise interventions, while some investigated the efect of dietary or behavioral interventions. The efect of diferent lifestyle infuencing modalities aimed to improve on the adverse efects of ADT varied greatly. Conclusions It is not possible to draw one conclusion on the efect of exercise-based interventions, but noted on several adverse efects of ADT improvement. Further studies are necessary to develop personalized lifestyle interventions in order to mitigate the adverse efects.