Background/Objectives: Over the past three decades, high survival rate of childhood brain tumors has been accompanied by long-term cardiometabolic co-morbidities, including obesity, cardiovascular diseases, type 2 diabetes, hypertension and metabolic syndrome. These co-morbidities can have a significant negative impact on the lifespan and quality of life of childhood brain tumor survivors. We conducted this systematic review to determine the effectiveness of lifestyle intervention, pharmacotherapy and bariatric surgery on lowering BMI z-score in survivors of childhood brain tumors. Design/Methods: This is a systematic review. The inclusion criteria including obese survivors of childhood brain tumor and comparing randomized controlled trials of lifestyle intervention, bariatric surgery, pharmacotherapy to obese non-cancer controls. The primary outcome measure is BMI z-score.We conducted a three-step search strategy: 1.Initial search conducted in Medline, followed by an analysis of the index terms used to describe articles 2.A second search using all identified keywords and index terms were then conducted in Medline, Embase, PsychINFO, CINAHL, Cochrane Review, DARE, PubMed, and Sport Discus 3.The reference lists of all identified articles were screened. Results: Using the above search strategy, 474 records were identified. A total of 234 records were found irrelevant and therefore excluded, as they did not discuss treating obesity in the survivors of childhood brain tumors. Instead, a majority of them explored obesity as a late effect after treatment for the brain tumors. Only one randomized controlled trial was identified. Conclusion: We conclude that there is limited evidence for treatment of obesity in this population. Based on this search strategy, we are widening the inclusion criteria to include non-RCT study designs such as case control, prospective cohort and retrospective cohort. This will allow us to systematically evaluate the interventions studied, so that we can design new intervention strategies to treat and prevent obesity and cardiometabolic disorders in the survivors of childhood brain tumors.