Background : The symptoms of myocardial infarction (MI) patients become worse after the cardiac events and potentially affect their morbidity and mortality. Exercise- based cardiac rehabilitation is one of the interventions to improve recovery among the MI patients. While the effect of exercise- based cardiac rehabilitation on heart rates and oxygen consumption has been confirmed, the evidence is inconclusive. Aims : The aim of this study was to identify the best available evidence regarding the effect of exercise- based cardiac rehabilitation for heart rates and oxygen consumption in patients with myocardial infarction. Methods : Reports on the interventions, published between year 1995 to 2016, on the four databases (Cochrane CENTRAL, Publishing Medline (PubMed), MEDLINE, and CINHIL) were used as the references. Comprehensive meta- analysis software version 3 was used to evaluate the heterogeneity of the included studies and to calculate standard mean differences (SMD) while considering effect size. The publication bias was assessed using a funnel plot visual inspection, Egger 's regression intercept test, and Fail- safe Numbers (Ns). Results : A total of 14 studies with 903 participants with follow- up of 3 weeks to 12 months were included. There was significant effect of exercise- based cardiac rehabilitation on heart rates (SMD= 1.076, SE= 0.120, 95% confidence interval (CI)= 0.841- 1.311, p= 0.000) and oxygen consumption (SMD= 0.900, SE= 0.273, 95% confidence interval (CI)= 0.365 - 1.436, p= 0.001). Conclusions : Exercise- based cardiac rehabilitation has a positive effect on heart rates and oxygen consumption. These results encourage future studies to consider the effect of exercise- based cardiac rehabilitation delivered in a home- based setting. (Table Presented) .