Several studies have focused on the difference in the alterations of health outcomes between usual care (UC) and home-based physical activity for survivors of early-stage breast cancer (ESBC), but the results are inconclusive. We performed the current research to comprehensively explore the difference with body composition, quality of life and fatigue as indices for health outcomes. The multiple databases were searched from the inception to Dec. 31 2015 with strict inclusion and exclusion criteria for literature retrieval. The Standardized Mean Difference (SMD) and corresponding 95% confidence interval (CI) for each parameter were calculated in 9 studies fulfilled the inclusion criteria. For body composition, no significant difference in the alterations of body mass index (BMI) (SMD = -0.069, p = 0.424) and percent body fat (SMD = -0.229, p = 0.117) between UC and home-based physical activity was observed for survivors of ESBC. With regard to the quality of life, compared with UC, the home-based physical activity intervention significantly improved the physical well-being (PWB) (SMD = 0.331, p = 0.004), social well-being (SWB) (SMD = 0.236, p = 0.038), emotional well-being (EWB) (SMD = 0.344, p = 0.003) and functional assessment of cancer therapy-general (FACT-G) (SMD = 0.490, p = 0.034) in ESBC survivors. As for the fatigue, the two interventions had similar effects on the FACT-fatigue (FACT-F) (SMD = -0.015, p = 0.945) in ESBC survivors. Our meta-analysis suggests that the home-based physical activity significantly improve quality of life for ESBC survivors but has no significant impact on the body composition and fatigue as compared to UC.