Rationale: The prevalence of obesity among individuals with chronic obstructive pulmonary disease (COPD) is increasing at a higher rate than in those without COPD. The combination of obesity and COPD may contribute to further physical inactivity, dyspnea, and functional impairments. This systematic review evaluated the effects of physical activity interventions on 6-Minute Walk Test (6MWT) distance, forced expiratory volume in the first second of expiration (FEV1), and body mass index (BMI) in overweight and obese COPD individuals. Methods: A systematic search of Embase (1974-present), Medline (1946-Present), CINAHL (1982-Present), AMED (1985- present) and PsycINFO (1987-Present) for controlled trials that involved any physical activity interventions for adults with COPD and obesity or overweight (completed June 11, 2016). Trials included participants at any stage of severity and stability of COPD, and conducted in any setting (inpatient, outpatient, community). Overall effects were determined by the weight mean difference (WMD) using Review Manage 5.3. Results: Fifteen studies with 1194 participants (age range 49- 88 years, 34-100% male) were included. Study quality ranged from fair (n=3) to good (n=12). Physical activity interventions were effective in increasing 6MWT distance (11 studies, 809 participants, WMD (95% CI) 24.04 m (0.73-47.34), P=0.04). There were no significant effects on FEV1 (3 studies, 80 participants, WMD (95% CI) 0.01L (-0.20-0.22), P=0.93) or BMI (2 studies, 90 participants, WMD (95% CI) -0.24 Kg/m2 (-1.26-0.79), P=0.65). Conclusions: Physical activity interventions improved 6MWT distance, although the clinical significance of the improvement is not clear. These results suggest that new approaches to physical activity interventions in overweight and obese individuals with COPD are needed.