Background: Dramatic economic growth in the past few decades has led to westernization of diets, increasingly sedentary lifestyle and a decrease in physical activity. As a result metabolic syndrome has emerged as a major global public health issue. The purpose of this systematic review is to examine the effect of physical activity on various metabolic syndrome outcomes which includes: blood pressure, triglyceride and HDL-C level, waist circumference, fasting blood glucose. This could help strategize future major researches and formulation of policies as basis for recommendation and prescribing physical activity interventions in both developed and developing countries. Methods: The systematic review mainly focused on the key metabolic syndrome outcomes: blood pressure, triglyceride and HDL-C level, waist circumference, fasting blood glucose. Aliterature search was conducted on the Pub Med database using predefined keywords. Retrieval of potential citations was followed by title, abstract and full-text screening. This procedure helped determine the eligibility of the articles for this systematic review. This was followed by data extraction from the eligible papers with the evidence appraisal conducted using the critical appraisal skills programme (CASP) tool for randomized controlled trial. Several factors were considered during data abstraction: Population (P), intervention (I), comparator (C), outcomes (O), study design (S). Results: Of the total 334 potential papers retrieved through PubMed search, only 14 papers were identified to be finally eligible for this systematic review. Data extraction and analysis provided a large body of evidence clearly supporting reduced risks of metabolic syndrome even with modest amounts of physical activity. An overall improvement was observed in all the five metabolic syndrome outcomes (blood pressure, triglyceride, HDL-C, fasting blood glucose, waist circumference) with majority of the studies focusing on physical activity that were aerobic in nature. Greater improvement in health benefits was observed with increase in the intensity of exercise or combining the physical activity with a wellness program that included a diet regimen. Conclusion: This review provides evidence that sustained physical activity for at least 12 weeks can independently lead to an improvement in overall metabolic syndrome as well as related risk factors.