Objective: To evaluate the effect of mindfulness therapy on schizophrenia. Methods: The relevant Chinese and English databases were retrieve，randomized controlled trials of the effect of mindfulness therapy on schizophrenia patients were collected，and ＲevMan 5. 3. 0 software was used for statistical processing. Ｒesults: Seven randomized controlled trials ( ＲCT) were included. Meta-analysis showed that compared with routine nursing measures，mindfulness therapy could alleviate anxiety level［MD = － 1. 05，95% CI( － 1. 43，－ 0. 67) ，P ＜ 0. 00001］，improve the patient＇s insight level［MD = － 12. 86， 95% CI( － 20. 91，－ 4. 81) ，P = 0. 002］and mindfulness level［MD = － 12. 56，95% CI( － 16. 88，－ 8. 25) ，P ＜ 0. 00001］. Conclusion: Mindfulness therapy can alleviate depression and anxiety，and improve the level of self-knowledge and self-esteem of schizophrenic patients