Aim The aim of this study was to evaluate efectiveness and safety of resistance training (RT). Data were retrieved from Medline, EMBASE, PubMed, CINAHL and Cochrane Central Register of Controlled Trials (Central) databases from inception to April 2020. Quantitative studies on RT for muscle strength, lean body mass, cardiopulmonary function, metabolism, quality of life, and pain in burned children were included in this study. Twelve RCTs (379 patients) were identifed. Meta-analysis showed RT signifcant increase in muscle strength [SMD=2.18, 95% CI (0.79, 3.56), p=0.002]. However, training showed no signifcant efect on muscle endurance [MD=10.00, 95% CI (− 0.22, 20.22), p=0.06]. Notably, training signifcantly increases total lean body mass [MD=2.10, 95% CI (1.28, 2.92), p<0.001]. In addition, training signifcantly increased leg lean body mass [MD=2.10, 95% CI (1.28, 2.92), p<0.001]. Moreover, training signifcantly increased VO2peak [MD=5.83, 95% CI (3.52, 8.13), p<0.001]. Meta-analysis showed that training signifcantly increases gait parameters, including stride length, step length, velocity and cadence. Furthermore, training signifcantly increased explosive capacity of lower limb muscles (p<0.001). Meta-analysis of 6-min walking test results showed that training signifcantly improves walking speed (p=0.0008). Notably, all studies showed unclear or high risk of bias; whereas, quality of the evidence was moderate or low. Analysis showed that RT signifcantly improves clinical outcomes. However, more high-quality, double-blind, randomized control trials should be performed to explore the efects of RT to ensure successful implementation in rehabilitation.