Background and Aims: Conduct a systematic review to determine the feasibility and effectiveness of high-intensity interval training (HIIT) on the post-stroke population. Methods: Data Sources: Academic Search Ultimate, CINAHL, and PubMed Central were searched April 2018-January 2019. Inclusion criteria included: studies published between 2010-2019, in English, participants were of the post-stroke population, and HIIT interventions. Study Selection: Thirteen studies were identified: six randomized controlled trials and seven outcome studies. PEDro scores ranged from three to eight. Points were commonly lost secondary to lack of blind subjects, therapists, and assessors. All articles were included in PEDro scoring, as well as two additional studies used as informational references. Data Extraction: Data was extracted by three authors and analyzed independently. Results: Nine studies performed HIIT on a treadmill, one cycling, one NuStep, one task-oriented, and one study on a stepper. HIIT improved VO2 max in the post-stroke population in five out of seven articles. Of the five, one study found continued improvement after one year. Participants in eight out of nine studies had improved walking performance following HIIT. Individually, four studies found gains in grip strength, skill retention, functional reach, and HR peak. HIIT has improved corticomotor excitability and nerve conduction latency in two separate studies. Conclusions: With proper pre-screening and monitoring, HIIT in poststroke rehabilitation proved to be both feasible and more effective than conventional therapy protocols. Incorporating principles of HIIT into treatment programs can improve walking performance, increase aerobic capacity, and overall quality of life.