Objectives • What aspects of caregiver health and well-being are commonly reported as affected by patient care? Develop an understanding of the aspects of caregiver health affected by patient care. • What is the evidence for meditative interventions as an intervention to improve caregiver well-being? Develop an understanding of the evidence for mindfulness interventions for caregivers. Systemic Review Background Informal caregivers and healthcare professionals providing direct patient care often report similar challenges in maintaining health; both populations report increased levels of stress and anxiety. Caregiver burnout, particularly in the palliative setting, has previously been identified as an area of heightened concern. Meditative interventions are gaining acceptance as a tool to improve well-being in a variety of clinical settings, however little is known about their effectiveness as an intervention for caregivers. Aims The objective of this review is to examine the effect of meditative interventions on measures of well-being for informal caregivers and healthcare professionals in the palliative setting as well as other caregiving environments. Among the outcomes examined are depression, stress, burnout, self-efficacy, job satisfaction, and sense of caregiving burden. Methods/Session Descriptions Of 1,561 articles retrieved from PubMed, EMBASE, PsycINFO and CINAHL, 68 articles met our inclusion criteria of a randomized clinical trial (RCT) or pre-post design, >5 participants, an isolatable meditative practice intervention and participants involved in direct patient care. After reviewing these articles in full text, 27 were eligible for inclusion in the systematic review, with 26 included in the meta-analysis. Conclusion Our review suggests there is evidence of improvement of mood and stress in both informal caregivers and healthcare professionals who undergo a meditative intervention. There is mixed evidence for improvement in perception of burden, burnout, and job satisfaction. It was unclear from the studies available whether changes in caregiver measures of well-being correlated with changes in the quality of patient care. There was a paucity of data around the effectiveness of these interventions in the palliative setting, suggesting an area where further research is needed.