二次检索
版本
人群分类
研究领域
证据类型
时间限定

作者:Olanrewaju, O

关键词:Sedentary behaviours · Older adults · Cognition · Review · Meta-analysis

发表时间:2020

发表期刊:Aging Clinical and Experimental Research

证据类型:系统评价/Meta分析

Background Physical activity can improve cognitive function of older adults, but the infuence of sedentary behaviour on cognition is less clear. This systematic review investigated associations between sedentary behaviour and cognitive function in older adults without dementia, and possible mechanisms involved. Methods Major databases were searched for studies in English between 01/01/1999 and 31/10/2019. The systematic review followed COSMOS-E guideline and a pre-registered protocol (CRD42019122229). Risk of bias was assessed using NICE Quality appraisal checklist. Findings were narratively synthesized and presented. Findings Eighteen studies comprised of 13 cross-sectional and fve longitudinal analyses (n=40,228). Evidence suggested varied associations between varied sedentary behaviours and cognitive function in older adults. 50% of study analyses did not control for physical activity. 3/18 studies demonstrated associations between higher sedentary levels and lower levels of brain biomarkers, while 1/18 showed auto-regulatory efect in the left hippocampus. Conducting a meta-analysis was not justifable due to considerable methodological, participant, outcome and exposure heterogeneity. Conclusion There is a lack of clarity about the overall and independent association between sedentary behaviour and cognition in older age. Underlying mechanisms are similar to physical activity and probably multi-modal. More studies with robust designs and methodology are needed to confrm efect of sedentary behaviour on cognition.