Purpose: The purpose of this review is to systematically summarize the physiological, psychological, social, and therapeutic benefits of Tai Chi from scientific literatures used Tai Chi as an intervention for older adults. Methods: A broad computerized literature search of Alt HealthWatch, ERIC, Medline, CINAHL, and PsycARTILES was conducted. Studies were selected if they met the following five criteria: 1) Tai Chi was used as an intervention, 2) Research design was either RCT or CCT, 3) Health benefits were used as an outcome measure, 4) Age group targeted older adults, and 5) Study was conducted in English speaking countries. Results: Fifty four articles were selected and reviewed. Among these studies, 11 articles proved that Tai Chi improves balance, strength, flexibility, and preventing of falls. Six articles reported Tai Chi enhances the cardiorespiratory function. 14 articles demonstrated that Tai Chi is associated with life satisfaction, stress reduction, decreasing anxiety and mood disturbance, and improving subjective well-being. 16 articles showed that Tai Chi is beneficial for a variety of chronic conditions, such as hypertension, arthritis, and insomnia. Seven articles mentioned the social benefits of Tai Chi practice supported by the evidence that most Tai Chi practitioners continue to practice in a group after the studies were completed. Conclusion: Regarding the increasing number of older population with many chronic health issues, Tai Chi may serve as a safe, low-cost, and effective program to improve the overall health and well-being for the elderly. In addition, Tai Chi can be considered as a holistic exercise modality to prevent disability and reduce medical expense through developing an active lifestyle among older people with chronic conditions.