Antidepressants are currently the treatment of choice for major depressive disorder (MDD). Nevertheless, a high percentage of patients do not respond to a first-line antidepressant drug, and combination treatments and augmentation strategies increase the risk of side effects. Moreover, a signific...

BACKGROUND: Shoulder dysfunction is a common problem in patients treated for head and neck cancer. Both neck dissections and radiotherapy can cause morbidity to the shoulder joint. Exercise interventions have been suggested as a treatment option for this population. OBJECTIVES: To evaluate the ef...

There is a view that exercise is less effective for weight loss in women compared with men. This systematic review examines the evidence for sex-based differences in the effect of exercise on body weight. We hypothesize that, when energy expenditure is equivalent, there will be no evidence for se...

This study appraises evidence for the effectiveness of exercise in improving quality of life (QoL) in persons with dementia (PwDs). The Cochrane, Medline, EMBASE, PsycINFO, and Cumulative Index to Nursing and Allied Health Literature databases were searched for peer-reviewed clinical trials of ex...

QUESTION: Can exercise or physical training improve physical function and prevent falls in older adults with visual impairments? DESIGN: Systematic review of randomised controlled trials with meta-analysis. PARTICIPANTS: Older adults (≥ 60 years) with visual impairments. INTERVENTION: Individual ...

Osteoporosis-related fractures represent a major health concern, particularly in elderly populations. Direct and indirect costs (amounting to nearly $17 billion in 2005), increased morbidity, and loss of independence place substantial burden on the health care system. Observational studies have s...

The aim of this meta-analysis was to examine the effects of nutritional and physical exercise interventions and interventions combining these interventions during radiotherapy treatment for patients with head and neck cancer on body composition, objectively measured physical function and nutritio...

BACKGROUND & AIMS: Exercise is an integral component of lifestyle intervention aimed at weight loss, but an independent benefit of exercise in NAFLD has also been suggested. METHODS: We aimed to evaluate the efficacy of aerobic exercise and/or progressive resistance training for the modulation of...

Purpose: This paper reviews and updates the evidence on the associations between physical activity and risk for cancer, and for mortality in persons with cancer, as presented in the 2018 Physical Activity Guidelines Advisory Committee Scientific Report . Methods: Systematic reviews of meta-ana...

Background Adult cancer patients consider diminished sleep quality as one of the most distressing symptoms they face. Furthermore, the significant correlation between insomnia and increased risk of death and loss to follow-up underscores the importance of enhancing sleep quality in this populat...